TMED10 (transmembrane p24 trafficking protein 10)

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TMED10 (transmembrane p24 trafficking protein 10)

2016-10-01 Affiliation

Identity

HGNC

LOCATION

14q24.3

LOCUSID

ALIAS

P24(DELTA),S31I125,S31III125,TMP21,Tmp-21-I,p23,p24d1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10972
MIM: 605406
HGNC: 16998
Ensembl: ENSG00000170348

Variants:

dbSNP: 10972
ClinVar: 10972
TCGA: ENSG00000170348
COSMIC: TMED10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000170348	ENST00000303575	P49755
ENSG00000170348	ENST00000303575	A0A024R6I3
ENSG00000170348	ENST00000555873	G3V2K7

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle Transport	REACTOME	R-HSA-204005
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Cargo concentration in the ER	REACTOME	R-HSA-5694530
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32293333	2020	The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.	8
32293333	2020	The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.	8
30821607	2019	Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.	16
30996093	2019	A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.	21
31472964	2019	TMP21 regulates autophagy by modulating ROS production and mTOR activation.	3
30821607	2019	Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.	16
30996093	2019	A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.	21
31472964	2019	TMP21 regulates autophagy by modulating ROS production and mTOR activation.	3
28233271	2018	A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.	9
28233271	2018	A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.	9
28115518	2017	TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.	11
28115518	2017	TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.	11
27569046	2016	3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.	20
27569046	2016	3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.	20
26617795	2015	TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway.	13

Citation

Dessen P

TMED10 (transmembrane p24 trafficking protein 10)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56626/gene-explorer/js/lib/jquery-3.5.1.min.js