CROCC (ciliary rootlet coiled-coil, rootletin)

ARTICLE CONTENTS

To the top

Other actions (beta)

Download as PDF

CROCC (ciliary rootlet coiled-coil, rootletin)

2016-10-01 Affiliation

Identity

HGNC

LOCATION

1p36.13

LOCUSID

ALIAS

ROLT,TAX1BP2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9696
MIM: 615776
HGNC: 21299
Ensembl: ENSG00000058453

Variants:

dbSNP: 9696
ClinVar: 9696
TCGA: ENSG00000058453
COSMIC: CROCC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000058453	ENST00000375541	Q5TZA2
ENSG00000058453	ENST00000445545	B1AKD8
ENSG00000058453	ENST00000467715	A0A087WU09
ENSG00000058453	ENST00000467938	A0A087WW81

Expression (GTEx)

0

10

20

30

40

50

60

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31799620	2020	Up-regulated microRNA-33b inhibits epithelial-mesenchymal transition in gallbladder cancer through down-regulating CROCC.	5
32325071	2020	Identification of a Structurally Dynamic Domain for Oligomer Formation in Rootletin.	7
31799620	2020	Up-regulated microRNA-33b inhibits epithelial-mesenchymal transition in gallbladder cancer through down-regulating CROCC.	5
32325071	2020	Identification of a Structurally Dynamic Domain for Oligomer Formation in Rootletin.	7
29463719	2018	STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.	35
29649211	2018	Stable centrosomal roots disentangle to allow interphase centriole independence.	8
29463719	2018	STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.	35
29649211	2018	Stable centrosomal roots disentangle to allow interphase centriole independence.	8
28089774	2017	Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.	9
28089774	2017	Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.	9
24240686	2014	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	1
24240686	2014	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	1
22610972	2012	The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2.	5
23070519	2012	C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.	23
22610972	2012	The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2.	5

Citation

Dessen P

CROCC (ciliary rootlet coiled-coil, rootletin)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56628/tumors-explorer/case-report-explorer/js/lib/all.min.js