SRP72 (signal recognition particle 72)

2016-12-01  

Identity

HGNC
SRP72
LOCATION
4q12
LOCUSID
6731
ALIAS
BMFF,BMFS1,HEL103
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6731
MIM: 602122
HGNC: 11303
Ensembl: ENSG00000174780

Variants:

dbSNP: 6731
ClinVar: 6731
TCGA: ENSG00000174780
COSMIC: SRP72

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174780ENST00000504757R4GNC1
ENSG00000174780ENST00000505314D6RDY6
ENSG00000174780ENST00000510663O76094
ENSG00000174780ENST00000642900O76094
ENSG00000174780ENST00000642900V9HWK0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
306494172019Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.16
306494172019Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.16
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.17
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.13
284941882017Depletion of signal recognition particle 72kDa increases radiosensitivity.6
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.17
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.13
284941882017Depletion of signal recognition particle 72kDa increases radiosensitivity.6
225415602012Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.49
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.8
225415602012Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.49
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.8
207292132010Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.14
210737482010Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.6
207292132010Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.14

Citation

Dessen P

SRP72 (signal recognition particle 72)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56663