CEP70 (centrosomal protein 70)

2017-01-01  

Identity

HGNC
CEP70
LOCATION
3q22.3
LOCUSID
80321
ALIAS
BITE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80321
MIM: 614310
HGNC: 29972
Ensembl: ENSG00000114107

Variants:

dbSNP: 80321
ClinVar: 80321
TCGA: ENSG00000114107
COSMIC: CEP70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114107ENST00000264982Q8NHQ1
ENSG00000114107ENST00000264982A0A140VJG2
ENSG00000114107ENST00000459695H7C4Y6
ENSG00000114107ENST00000462419C9J710
ENSG00000114107ENST00000464035Q8NHQ1
ENSG00000114107ENST00000468900C9J966
ENSG00000114107ENST00000470159C9JZ04
ENSG00000114107ENST00000474781Q8NHQ1
ENSG00000114107ENST00000481834Q8NHQ1
ENSG00000114107ENST00000484888Q8NHQ1
ENSG00000114107ENST00000484888A0A140VJG2
ENSG00000114107ENST00000485115C9J0F4
ENSG00000114107ENST00000489254B7Z2D2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381228992024Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters.0
381228992024Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters.0
369678012023Identification of biallelic variations of CEP70 in patients with male infertility.1
376472182023BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer control.1
369678012023Identification of biallelic variations of CEP70 in patients with male infertility.1
376472182023BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer control.1
339808142021Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.5
339808142021Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis.5
280637372017Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer.7
286321502017Centrosomal Protein 70 Is a Mediator of Paclitaxel Sensitivity.4
280637372017Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer.7
286321502017Centrosomal Protein 70 Is a Mediator of Paclitaxel Sensitivity.4
268932882016Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization.9
268932882016Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization.9
261126042015Cep70 regulates microtubule stability by interacting with HDAC6.11

Citation

Dessen P

CEP70 (centrosomal protein 70)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56716/meetings/case-report-explorer/css/lib/bootstrap.min.css