SLC47A1 (solute carrier family 47 member 1)

2017-04-01 Affiliation

Identity

HGNC

SLC47A1

LOCATION

17p11.2

LOCUSID

55244

ALIAS

MATE1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55244
MIM: 609832
HGNC: 25588
Ensembl: ENSG00000142494

Variants:

dbSNP: 55244
ClinVar: 55244
TCGA: ENSG00000142494
COSMIC: SLC47A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000142494	ENST00000270570	Q96FL8
ENSG00000142494	ENST00000395585	Q96FL8
ENSG00000142494	ENST00000436810	E7EX57
ENSG00000142494	ENST00000571335	J3KSS8
ENSG00000142494	ENST00000575023	I3L345
ENSG00000142494	ENST00000581558	J3KRZ3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated	PK	PD	22882994, 23267855, 23873119, 26004431, 28834135
PA445376	Polycystic Ovary Syndrome	Disease	ClinicalAnnotation	associated	PK	PD	22882994, 23267855, 23873119, 26004431, 28834135
PA450395	metformin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway	associated	PK	PD	22722338, 22882994, 23267855, 23873119, 24624919, 26004431, 28834135

References

Pubmed ID	Year	Title	Citations
36786075	2023	The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow-up study.	2
36786075	2023	The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow-up study.	2
35163393	2022	Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.	6
36575162	2022	The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.	33
35163393	2022	Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.	6
36575162	2022	The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.	33
32708212	2020	Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.	7
32708212	2020	Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.	7
30910922	2019	Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.	9
30910922	2019	Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.	9
29070695	2018	Relationship between DNA Methylation in the 5' CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver.	4
29704007	2018	Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO).	10
30433870	2018	Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients.	7
29070695	2018	Relationship between DNA Methylation in the 5' CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver.	4
29704007	2018	Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO).	10

Citation

Dessen P

SLC47A1 (solute carrier family 47 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56745/gene-explorer/css/lib/teaching-explorer/