Identity
HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
ARCL2B,ARCL3B,P5C,P5CR,PIG45,PP222,PRO3,PYCR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5831
MIM: 179035
HGNC: 9721
Ensembl: ENSG00000183010
Variants:
dbSNP: 5831
ClinVar: 5831
TCGA: ENSG00000183010
COSMIC: PYCR1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37982568 | 2024 | PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study. | 0 |
| 37982568 | 2024 | PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study. | 0 |
| 36994814 | 2023 | LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis. | 0 |
| 37517099 | 2023 | Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients. | 3 |
| 37777542 | 2023 | IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. | 1 |
| 37845207 | 2023 | Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. | 2 |
| 36994814 | 2023 | LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis. | 0 |
| 37517099 | 2023 | Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients. | 3 |
| 37777542 | 2023 | IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. | 1 |
| 37845207 | 2023 | Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. | 2 |
| 35108535 | 2022 | Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. | 24 |
| 35760868 | 2022 | Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. | 37 |
| 36104652 | 2022 | The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer. | 4 |
| 36227136 | 2022 | SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3. | 3 |
| 35108535 | 2022 | Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. | 24 |
Citation
Dessen P
PYCR1 (pyrroline-5-carboxylate reductase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56746/pycr1-(pyrroline-5-carboxylate-reductase-1)
