HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)

2017-04-01  

Identity

HGNC
HCN2
LOCATION
19p13.3
LOCUSID
610
ALIAS
BCNG-2,BCNG2,HAC-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 610
MIM: 602781
HGNC: 4846
Ensembl: ENSG00000099822

Variants:

dbSNP: 610
ClinVar: 610
TCGA: ENSG00000099822
COSMIC: HCN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099822ENST00000251287Q9UL51

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
HCN channelsREACTOMER-HSA-1296061

References

Pubmed IDYearTitleCitations
356623392022HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling.5
356623392022HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling.5
319168532020HCN2 and TBX3 Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells.5
325437422020Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).10
319168532020HCN2 and TBX3 Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells.5
325437422020Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).10
316829552019Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.2
316829552019Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.2
290471472018Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.4
290646162018Gain-of-function HCN2 variants in genetic epilepsy.8
290471472018Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.4
290646162018Gain-of-function HCN2 variants in genetic epilepsy.8
280177182017Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).4
288647722017Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.20
290544092017Dual expression of constitutively active Gα(s)-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment.1

Citation

Dessen P

HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56751