DZIP3 (DAZ interacting zinc finger protein 3)

2017-04-01  

Identity

HGNC
DZIP3
LOCATION
3q13.13
LOCUSID
9666
ALIAS
PPP1R66,UURF2,hRUL138
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9666
MIM: 608672
HGNC: 30938
Ensembl: ENSG00000198919

Variants:

dbSNP: 9666
ClinVar: 9666
TCGA: ENSG00000198919
COSMIC: DZIP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198919ENST00000361582Q86Y13
ENSG00000198919ENST00000463306Q86Y13
ENSG00000198919ENST00000479138C9J9M8
ENSG00000198919ENST00000486815C9JRX4
ENSG00000198919ENST00000495008Q86Y13
ENSG00000198919ENST00000497905C9J702

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368413242023Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.0
368413242023Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.0
330672652021RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.9
330672652021RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.9
332296272020DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.4
332296272020DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.4
182069702008Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.176
182069702008Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.176

Citation

Dessen P

DZIP3 (DAZ interacting zinc finger protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56754/js/gene-explorer/js/web-card-_common.js