BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)

2017-04-01 Affiliation

Identity

HGNC

BUD23

LOCATION

7q11.23

LOCUSID

114049

ALIAS

HASJ4442,HUSSY-3,MERM1,PP3381,WBMT,WBSCR22

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 114049
MIM: 615733
HGNC: 16405
Ensembl: ENSG00000071462

Variants:

dbSNP: 114049
ClinVar: 114049
TCGA: ENSG00000071462
COSMIC: BUD23

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000071462	ENST00000265758	O43709
ENSG00000071462	ENST00000421304	F8VZ18
ENSG00000071462	ENST00000421744	F8WD87
ENSG00000071462	ENST00000423497	O43709
ENSG00000071462	ENST00000428163	F8WD67
ENSG00000071462	ENST00000430270	F8W1Y1
ENSG00000071462	ENST00000430446	H7C439
ENSG00000071462	ENST00000432522	E9PCQ7
ENSG00000071462	ENST00000436944	B3KR83
ENSG00000071462	ENST00000441822	F2Z3D9
ENSG00000071462	ENST00000442099	H7C170
ENSG00000071462	ENST00000453316	H7C0G4

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
rRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6790901
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35088887	2022	WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.	19
35088887	2022	WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.	19
31939735	2020	Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.	8
32380188	2020	WBSCR22 confers cell survival and predicts poor prognosis in glioma.	15
31939735	2020	Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.	8
32380188	2020	WBSCR22 confers cell survival and predicts poor prognosis in glioma.	15
30535232	2019	Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.	1
30535232	2019	Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.	1
29133897	2017	WBSCR22 confers oxaliplatin resistance in human colorectal cancer.	26
29133897	2017	WBSCR22 confers oxaliplatin resistance in human colorectal cancer.	26
25352209	2015	Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.	4
25525153	2015	WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA.	74
25851604	2015	The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.	81
26214185	2015	The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.	18
25352209	2015	Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.	4

Citation

Dessen P

BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56847/meetings/