RFX5 (regulatory factor X5)

2017-04-01  

Identity

HGNC
RFX5
LOCATION
1q21.3
LOCUSID
5993
ALIAS
-

Other Information

Locus ID:

NCBI: 5993
MIM: 601863
HGNC: 9986
Ensembl: ENSG00000143390

Variants:

dbSNP: 5993
ClinVar: 5993
TCGA: ENSG00000143390
COSMIC: RFX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143390ENST00000290524P48382
ENSG00000143390ENST00000368870P48382
ENSG00000143390ENST00000392746F8W689
ENSG00000143390ENST00000412774A0A0A0MSM9
ENSG00000143390ENST00000421986F8WFE4
ENSG00000143390ENST00000422595A0A0A0MSQ2
ENSG00000143390ENST00000430227F6X9D6
ENSG00000143390ENST00000435314F8WDU3
ENSG00000143390ENST00000436271F6S3S0
ENSG00000143390ENST00000436637H0Y4B4
ENSG00000143390ENST00000437327A0A0A0MT34
ENSG00000143390ENST00000444392F2Z2G0
ENSG00000143390ENST00000450506F6UE82
ENSG00000143390ENST00000452456F2Z2G0
ENSG00000143390ENST00000452671P48382
ENSG00000143390ENST00000458484F6R6G4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Primary immunodeficiencyKEGGko05340
Antigen processing and presentationKEGGhsa04612
Primary immunodeficiencyKEGGhsa05340
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360454002022Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma.1
360454002022Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma.1
328839832020RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.13
329521122020RFX5 regulates gene expression of the Pcdhα cluster.0
328839832020RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.13
329521122020RFX5 regulates gene expression of the Pcdhα cluster.0
278409832017The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.12
278409832017The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.12
239113942013Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5.5
239113942013Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5.5
230796212012SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells.12
230796212012SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells.12
207323282010Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.4
207323282010Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.4
190413272009HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells.34

Citation

Dessen P

RFX5 (regulatory factor X5)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56872