BCAT2 (branched chain amino acid transaminase 2)

2017-08-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
BCAM,BCATM,BCT2,HVLI,PP18
FUSION GENES

Other Information

Locus ID:

NCBI: 587
MIM: 113530
HGNC: 977
Ensembl: ENSG00000105552

Variants:

dbSNP: 587
ClinVar: 587
TCGA: ENSG00000105552
COSMIC: BCAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105552ENST00000316273O15382
ENSG00000105552ENST00000402551B3KSI3
ENSG00000105552ENST00000545387O15382
ENSG00000105552ENST00000593515M0QXF9
ENSG00000105552ENST00000597011B3KSI3
ENSG00000105552ENST00000598162M0QZ10
ENSG00000105552ENST00000599246M0QZP4
ENSG00000105552ENST00000601681M0R2K7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Valine, leucine and isoleucine degradationKEGGko00280
Valine, leucine and isoleucine biosynthesisKEGGko00290
Pantothenate and CoA biosynthesisKEGGko00770
Valine, leucine and isoleucine degradationKEGGhsa00280
Valine, leucine and isoleucine biosynthesisKEGGhsa00290
Pantothenate and CoA biosynthesisKEGGhsa00770
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Leucine degradation, leucine => acetoacetate + acetyl-CoAKEGGhsa_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoAKEGGM00036
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Branched-chain amino acid catabolismREACTOMER-HSA-70895

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379263612024Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development.1
379263612024Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development.1
378010832023BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions.0
378010832023BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions.0
343407272022Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance.0
343407272022Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance.0
330978332021Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells.85
345112902021Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults.2
330978332021Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells.85
345112902021Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults.2
319291812020Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase.2
320298962020BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.76
324675622020Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth.42
319291812020Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase.2
320298962020BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.76

Citation

Dessen P

BCAT2 (branched chain amino acid transaminase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56927/js/lib/teaching-explorer/cancer-prone-explorer/