CHRDL1 (chordin like 1)

2017-08-01  

Identity

HGNC
CHRDL1
LOCATION
Xq23
LOCUSID
91851
ALIAS
CHL,MGC1,MGCN,NRLN1,VOPT,dA141H5.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91851
MIM: 300350
HGNC: 29861
Ensembl: ENSG00000101938

Variants:

dbSNP: 91851
ClinVar: 91851
TCGA: ENSG00000101938
COSMIC: CHRDL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101938ENST00000372042Q9BU40
ENSG00000101938ENST00000372045A0A452Q6Z9
ENSG00000101938ENST00000394797Q9BU40
ENSG00000101938ENST00000444321Q9BU40
ENSG00000101938ENST00000482160Q9BU40

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355108122023Study on the expression and function of chordin-like 1 in oral squamous cell carcinoma.1
367492222023Bioinformatics identify the role of chordin-like 1 in thyroid cancer.0
355108122023Study on the expression and function of chordin-like 1 in oral squamous cell carcinoma.1
367492222023Bioinformatics identify the role of chordin-like 1 in thyroid cancer.0
284235642017Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer.29
284235642017Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer.29
269558892016Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth.12
269766382016Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.31
269558892016Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth.12
269766382016Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.31
240735972015X-linked Megalocornea Associated with the Novel CHRDL1 Gene Mutation p.(Pro56Leu*8).5
257121322015Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model.14
260208252015Novel Mutation in the CHRDL1 Gene Detected in Patients With Megalocornea.3
240735972015X-linked Megalocornea Associated with the Novel CHRDL1 Gene Mutation p.(Pro56Leu*8).5
257121322015Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model.14

Citation

Dessen P

CHRDL1 (chordin like 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56935