ATG13 (autophagy related 13)

2017-08-01  

Identity

HGNC
ATG13
LOCATION
11p11.2
LOCUSID
9776
ALIAS
KIAA0652,PARATARG8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9776
MIM: 615088
HGNC: 29091
Ensembl: ENSG00000175224

Variants:

dbSNP: 9776
ClinVar: 9776
TCGA: ENSG00000175224
COSMIC: ATG13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175224ENST00000359513O75143
ENSG00000175224ENST00000395549J9JIF6
ENSG00000175224ENST00000524625O75143
ENSG00000175224ENST00000525009H0YEM7
ENSG00000175224ENST00000526508O75143
ENSG00000175224ENST00000528494O75143
ENSG00000175224ENST00000529395H0YCL5
ENSG00000175224ENST00000529655O75143
ENSG00000175224ENST00000530500O75143
ENSG00000175224ENST00000531933H0YDR0
ENSG00000175224ENST00000532067H0YF43
ENSG00000175224ENST00000533325E9PPR2
ENSG00000175224ENST00000577256J3KRU6
ENSG00000175224ENST00000578626J3KST9
ENSG00000175224ENST00000580238A0A1B0GXJ3
ENSG00000175224ENST00000581416J3QRL1
ENSG00000175224ENST00000581438J3QLH7
ENSG00000175224ENST00000582547J3QR83
ENSG00000175224ENST00000583249J3QR16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

References

Pubmed IDYearTitleCitations
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
352203972022Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.11
354874432022Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).8
361698012022The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.2
352203972022Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.11
354874432022Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE).8
361698012022The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.2
323203092021ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.10
325432672021LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.25
336821332021The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.2
323203092021ATG13 dynamics in nonselective autophagy and mitophagy: insights from live imaging studies and mathematical modeling.10
325432672021LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.25

Citation

Dessen P

ATG13 (autophagy related 13)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56942/gene-fusions/js/lib/case-report-explorer/