UBE2Z (ubiquitin conjugating enzyme E2 Z)

2017-08-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
HOYS7,USE1
FUSION GENES

Other Information

Locus ID:

NCBI: 65264
MIM: 611362
HGNC: 25847
Ensembl: ENSG00000159202

Variants:

dbSNP: 65264
ClinVar: 65264
TCGA: ENSG00000159202
COSMIC: UBE2Z

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159202ENST00000360943Q9H832
ENSG00000159202ENST00000504684I3L3V3
ENSG00000159202ENST00000506498H0Y9X8
ENSG00000159202ENST00000508468D6RB11
ENSG00000159202ENST00000511373I3L4C5
ENSG00000159202ENST00000514948I3L286

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
318311682020Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.7
323924392020The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.1
318311682020Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.7
323924392020The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.1
321278212019Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.1
321278212019Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.1
283762052017Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.10
288401292017Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.6
283762052017Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.10
288401292017Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.6
266028832015Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.3
266028832015Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.3
171606262007Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).4
175977592007Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.179
171606262007Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).4

Citation

Dessen P

UBE2Z (ubiquitin conjugating enzyme E2 Z)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57024/js/lib/favicon/case-report-explorer/