PRIMPOL (primase and DNA directed polymerase)

2017-08-01  

Identity

HGNC
PRIMPOL
LOCATION
4q35.1
LOCUSID
201973
ALIAS
CCDC111,MYP22,Primpol1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 201973
MIM: 615421
HGNC: 26575
Ensembl: ENSG00000164306

Variants:

dbSNP: 201973
ClinVar: 201973
TCGA: ENSG00000164306
COSMIC: PRIMPOL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164306ENST00000314970Q96LW4
ENSG00000164306ENST00000503752Q96LW4
ENSG00000164306ENST00000506278D6R908
ENSG00000164306ENST00000508001H0Y9N8
ENSG00000164306ENST00000509002D6R971
ENSG00000164306ENST00000512834Q96LW4
ENSG00000164306ENST00000515152D6R908
ENSG00000164306ENST00000515774D3DP56

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379712912024PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass.0
381808182024USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress.3
384927182024PrimPol Variant V102A with Altered Primase and Polymerase Activities.0
379712912024PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass.0
381808182024USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress.3
384927182024PrimPol Variant V102A with Altered Primase and Polymerase Activities.0
373260282023The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis.2
377583132023Regulation of Human DNA Primase-Polymerase PrimPol.0
381052102023Response of PRIMPOL-Knockout Human Lung Adenocarcinoma A549 Cells to Genotoxic Stress.0
3820322520233'dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol.0
373260282023The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis.2
377583132023Regulation of Human DNA Primase-Polymerase PrimPol.0
381052102023Response of PRIMPOL-Knockout Human Lung Adenocarcinoma A549 Cells to Genotoxic Stress.0
3820322520233'dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol.0
366477182022PRIMPOL competes with RAD51 to resolve G-quadruplex-induced replication stress via its interaction with RPA.1

Citation

Dessen P

PRIMPOL (primase and DNA directed polymerase)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57026