KCNC4 (potassium voltage-gated channel subfamily C member 4)

2017-08-01  

Identity

HGNC
KCNC4
LOCATION
1p13.3
LOCUSID
3749
ALIAS
C1orf30,HKSHIIIC,KSHIIIC,KV3.4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3749
MIM: 176265
HGNC: 6236
Ensembl: ENSG00000116396

Variants:

dbSNP: 3749
ClinVar: 3749
TCGA: ENSG00000116396
COSMIC: KCNC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116396ENST00000369787Q03721
ENSG00000116396ENST00000413138H7BZ66
ENSG00000116396ENST00000438661Q03721
ENSG00000116396ENST00000469655Q03721
ENSG00000116396ENST00000636402A0A1B0GVB7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072

References

Pubmed IDYearTitleCitations
361985002022Tunable Action Potential Repolarization Governed by Kv3.4 Channels in Dorsal Root Ganglion Neurons.3
361985002022Tunable Action Potential Repolarization Governed by Kv3.4 Channels in Dorsal Root Ganglion Neurons.3
333686322021PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.1
333686322021PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.1
314713342019HIF-1α Regulates Proliferation and Invasion of Oral Cancer Cells through Kv3.4 Channel.9
314713342019HIF-1α Regulates Proliferation and Invasion of Oral Cancer Cells through Kv3.4 Channel.9
266484582016Expression of the voltage-gated potassium channel Kv3.4 in oral leucoplakias and oral squamous cell carcinomas.5
266484582016Expression of the voltage-gated potassium channel Kv3.4 in oral leucoplakias and oral squamous cell carcinomas.5
256096402015Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.33
256096402015Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.33
234438532013Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells.16
234438532013Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells.16
219129652012Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.19
224734242012Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.10
219129652012Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.19

Citation

Dessen P

KCNC4 (potassium voltage-gated channel subfamily C member 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57047