DCAF4 (DDB1 and CUL4 associated factor 4)

2017-10-01  

Identity

HGNC
DCAF4
LOCATION
14q24.2
LOCUSID
26094
ALIAS
WDR21,WDR21A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26094
MIM: 616372
HGNC: 20229
Ensembl: ENSG00000119599

Variants:

dbSNP: 26094
ClinVar: 26094
TCGA: ENSG00000119599
COSMIC: DCAF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119599ENST00000353777Q86SY2
ENSG00000119599ENST00000358377Q8WV16
ENSG00000119599ENST00000394234Q8WV16
ENSG00000119599ENST00000509153Q8WV16
ENSG00000119599ENST00000509320D6RCB5
ENSG00000119599ENST00000553457G3V3D6
ENSG00000119599ENST00000555042Q8WV16

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalClinicalAnnotationassociatedPD22366774
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD22366774

References

Pubmed IDYearTitleCitations
283836842017Functional variants in DCAF4 associated with lung cancer risk in European populations.11
283836842017Functional variants in DCAF4 associated with lung cancer risk in European populations.11
256244622015DCAF4, a novel gene associated with leucocyte telomere length.44
256244622015DCAF4, a novel gene associated with leucocyte telomere length.44
223667742012Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.1
223667742012Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.1

Citation

Dessen P

DCAF4 (DDB1 and CUL4 associated factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57059/gene-fusions/css/lib/js/web-card-gene.js