MARCO (macrophage receptor with collagenous structure)

2017-10-01  

Identity

HGNC
MARCO
LOCATION
2q14.2
LOCUSID
8685
ALIAS
SCARA2,SR-A6

Other Information

Locus ID:

NCBI: 8685
MIM: 604870
HGNC: 6895
Ensembl: ENSG00000019169

Variants:

dbSNP: 8685
ClinVar: 8685
TCGA: ENSG00000019169
COSMIC: MARCO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000019169ENST00000327097Q9UEW3
ENSG00000019169ENST00000327097Q4ZG40
ENSG00000019169ENST00000412481C9JKT8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372125982023Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.5
372125982023Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.5
353647812022Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.2
353647812022Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.2
332934262021Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.78
340114002021Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.40
343984032021TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.5
346265852021Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.14
332934262021Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.78
340114002021Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.40
343984032021TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.5
346265852021Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.14
327404542020Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.3
333115582020Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.20
333635392020Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.6

Citation

Dessen P

MARCO (macrophage receptor with collagenous structure)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57064