LACTB (lactamase beta)

2017-10-01  

Identity

HGNC
LACTB
LOCATION
15q22.2
LOCUSID
114294
ALIAS
G24,MRPL56
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114294
MIM: 608440
HGNC: 16468
Ensembl: ENSG00000103642

Variants:

dbSNP: 114294
ClinVar: 114294
TCGA: ENSG00000103642
COSMIC: LACTB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103642ENST00000261893P83111
ENSG00000103642ENST00000413507P83111
ENSG00000103642ENST00000557972H0YNN5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381764152024OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.3
381764152024OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.3
362823642023LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.1
363758422023LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.0
371579502023PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.3
362823642023LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.1
363758422023LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.0
371579502023PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.3
332597192022Clinical Significance of β-Lactamase Expression in Colorectal Cancer.1
352473272022Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.5
360888052022LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.4
365346962022The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.5
332597192022Clinical Significance of β-Lactamase Expression in Colorectal Cancer.1
352473272022Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.5
360888052022LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.4

Citation

Dessen P

LACTB (lactamase beta)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57106