CYBRD1 (cytochrome b reductase 1)

2017-10-01  

Identity

HGNC
CYBRD1
LOCATION
2q31.1
LOCUSID
79901
ALIAS
CYB561A2,DCYTB,FRRS3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79901
MIM: 605745
HGNC: 20797
Ensembl: ENSG00000071967

Variants:

dbSNP: 79901
ClinVar: 79901
TCGA: ENSG00000071967
COSMIC: CYBRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071967ENST00000321348Q53TN4
ENSG00000071967ENST00000375252Q53TN4
ENSG00000071967ENST00000409484Q53TN4
ENSG00000071967ENST00000445146C9JML1

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365932422023DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancer.7
365932422023DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancer.7
347149552021miR-423-3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1.7
347149552021miR-423-3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1.7
305447992018Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures.15
305447992018Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures.15
274390172017Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C.3
282702172017DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.19
289371592017Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells.5
274390172017Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C.3
282702172017DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.19
289371592017Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells.5
230123982013Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.1
230123982013Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.1
227736072012CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.15

Citation

Dessen P

CYBRD1 (cytochrome b reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57205