USP21 (ubiquitin specific peptidase 21)

2018-02-01  

Identity

HGNC
USP21
LOCATION
1q23.3
LOCUSID
27005
ALIAS
USP16,USP23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27005
MIM: 604729
HGNC: 12620
Ensembl: ENSG00000143258

Variants:

dbSNP: 27005
ClinVar: 27005
TCGA: ENSG00000143258
COSMIC: USP21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143258ENST00000289865Q9UK80
ENSG00000143258ENST00000368001Q9UK80
ENSG00000143258ENST00000368002Q9UK80
ENSG00000143258ENST00000479344V9GYJ6
ENSG00000143258ENST00000486299A0A1W2PRX0
ENSG00000143258ENST00000492950V9GY36
ENSG00000143258ENST00000493054A0A1W2PQ32

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379644662024Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling.0
379644662024Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling.0
362854442023Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.0
374345572023c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.2
362854442023Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.0
374345572023c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.2
348253422022USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer.10
359740012022USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1.9
360959352022USP21 accelerates the proliferation and glycolysis of esophageal cancer cells by regulating the STAT3/FOXO1 pathway.3
348253422022USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer.10
359740012022USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1.9
360959352022USP21 accelerates the proliferation and glycolysis of esophageal cancer cells by regulating the STAT3/FOXO1 pathway.3
330520172021USP21 upregulation in cholangiocarcinoma promotes cell proliferation and migration in a deubiquitinase-dependent manner.7
333897942021USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma.6
335822172021Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.8

Citation

Dessen P

USP21 (ubiquitin specific peptidase 21)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57285