DSN1 (DSN1 component of MIS12 kinetochore complex)

2018-02-01  

Identity

HGNC
DSN1
LOCATION
20q11.23
LOCUSID
79980
ALIAS
C20orf172,KNL3,MIS13,dJ469A13.2,hKNL-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79980
MIM: 609175
HGNC: 16165
Ensembl: ENSG00000149636

Variants:

dbSNP: 79980
ClinVar: 79980
TCGA: ENSG00000149636
COSMIC: DSN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149636ENST00000373734Q9H410
ENSG00000149636ENST00000373740Q5JW54
ENSG00000149636ENST00000373750Q9H410
ENSG00000149636ENST00000426836Q9H410
ENSG00000149636ENST00000438549Q5JW57
ENSG00000149636ENST00000447406Q5JW53
ENSG00000149636ENST00000448110Q9H410

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355091012022SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner.9
355091012022SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner.9
342386862021DSN1 is a prognostic biomarker and correlated with clinical characterize in breast cancer.1
342386862021DSN1 is a prognostic biomarker and correlated with clinical characterize in breast cancer.1
331534002020Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.7
331534002020Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.7
301366462018Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma.6
301366462018Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma.6
273295862016Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.41
273295862016Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.41
186409742008Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore.46
186409742008Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore.46

Citation

Dessen P

DSN1 (DSN1 component of MIS12 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57289