BEX3 (brain expressed X-linked 3)

2018-02-01  

Identity

HGNC
BEX3
LOCATION
Xq22.2
LOCUSID
27018
ALIAS
Bex,DXS6984E,HGR74,NADE,NGFRAP1

Other Information

Locus ID:

NCBI: 27018
MIM: 300361
HGNC: 13388
Ensembl: ENSG00000166681

Variants:

dbSNP: 27018
ClinVar: 27018
TCGA: ENSG00000166681
COSMIC: BEX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166681ENST00000361298Q00994
ENSG00000166681ENST00000372634Q00994
ENSG00000166681ENST00000372635Q00994
ENSG00000166681ENST00000372645Q00994

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NADE modulates death signallingREACTOMER-HSA-205025

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
331002282020Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.8
331002282020Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.8
280839952017BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma.12
280839952017BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma.12
167770772006Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE.4
167770772006Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE.4
127390052003NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.7
127390052003NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.7
118305822002Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.16
118305822002Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.16

Citation

Dessen P

BEX3 (brain expressed X-linked 3)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57308