ATG3 (autophagy related 3)

2018-02-01  

Identity

HGNC
LOCATION
3q13.2
LOCUSID
ALIAS
APG3,APG3-LIKE,APG3L,PC3-96
FUSION GENES

Other Information

Locus ID:

NCBI: 64422
MIM: 609606
HGNC: 20962
Ensembl: ENSG00000144848

Variants:

dbSNP: 64422
ClinVar: 64422
TCGA: ENSG00000144848
COSMIC: ATG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144848ENST00000283290Q9NT62
ENSG00000144848ENST00000402314Q9NT62
ENSG00000144848ENST00000492886C9JNW8
ENSG00000144848ENST00000496423F8WDI0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
345554232022Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.13
345554232022Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.13
333820732021Overexpression of miR-431 attenuates hypoxia/reoxygenation-induced myocardial damage via autophagy-related 3.5
334466362021An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.17
333820732021Overexpression of miR-431 attenuates hypoxia/reoxygenation-induced myocardial damage via autophagy-related 3.5
334466362021An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.17
315494072020LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma.56
322581302020Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells.11
315494072020LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma.56
322581302020Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells.11
307949142019Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.39
307949142019Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.39
291388332018miR-16 mimics inhibit TGF-β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells.18
293007892018Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.53
297127762018eIF5A is required for autophagy by mediating ATG3 translation.42

Citation

Dessen P

ATG3 (autophagy related 3)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57331/teaching-explorer/case-report-explorer/js/lib/jquery-3.5.1.min.js