CETP (cholesteryl ester transfer protein)

2018-02-01  

Identity

HGNC
CETP
LOCATION
16q13
LOCUSID
1071
ALIAS
BPIFF,HDLCQ10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1071
MIM: 118470
HGNC: 1869
Ensembl: ENSG00000087237

Variants:

dbSNP: 1071
ClinVar: 1071
TCGA: ENSG00000087237
COSMIC: CETP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087237ENST00000200676P11597
ENSG00000087237ENST00000200676A0A0S2Z3F6
ENSG00000087237ENST00000379780P11597
ENSG00000087237ENST00000379780A0A0S2Z3I8
ENSG00000087237ENST00000566128H3BRJ9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223
LDL-mediated lipid transportREACTOMER-HSA-171052

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD14660992, 20195290
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD14660992, 15044381, 15856070, 18957472, 9420339
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD15856070, 16002074, 17931083
PA444517Hyperlipoproteinemia Type IIDiseaseClinicalAnnotationassociatedPD15856070, 17931083
PA444528HyperlipidemiasDiseaseClinicalAnnotationassociatedPD20195290
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD12663600, 15856070, 16103896
PA449688fluvastatinChemicalClinicalAnnotationassociatedPD16002074
PA450272lovastatinChemicalClinicalAnnotationassociatedPD16103896
PA451089pravastatinChemicalClinicalAnnotationassociatedPD14660992, 15044381, 15856070, 18957472, 9420339
PA451363simvastatinChemicalClinicalAnnotationassociatedPD15856070, 17931083

References

Pubmed IDYearTitleCitations
382653392024CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease.1
382653392024CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease.1
363185072023Elevated Serum Low-Density Lipoproteins-Cholesterol Levels and B1B2/B2B2 CETP Genotype Are Positively Associated with Nonalcoholic Fatty Liver Disease in Women with Gallstone Disease.1
366529342023Abdominal Obesity, Excessive Adiposity, and the Taq1B CETP Variant Are Positively Associated with Serum Lipid Levels in Mexican Women.1
368812782023Structure-based mechanism and inhibition of cholesteryl ester transfer protein.7
370548802023Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice.0
372504942023A Polynesian-specific missense CETP variant alters the lipid profile.0
373734322023Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk.1
374079532023Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus.0
374460942023Association of Common Variants of APOE, CETP, and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study.3
376397522023Structural insights on the deformations induced by various mutations on cholesteryl ester transfer protein.1
378337392023Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents.1
379297822023Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene.0
380393002023Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP.0
380570132023Association of dyslipidemia with single nucleotide polymorphisms of the cholesteryl ester transfer protein gene and cardiovascular disease risk factors in a highly admixed population.1

Citation

Dessen P

CETP (cholesteryl ester transfer protein)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57338