ATP5IF1 (ATP synthase inhibitory factor subunit 1)

2018-02-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
ATPI,ATPIF1,ATPIP,IP

Other Information

Locus ID:

NCBI: 93974
MIM: 614981
HGNC: 871
Ensembl: ENSG00000130770

Variants:

dbSNP: 93974
ClinVar: 93974
TCGA: ENSG00000130770
COSMIC: ATP5IF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130770ENST00000335514Q9UII2
ENSG00000130770ENST00000465645Q9UII2
ENSG00000130770ENST00000468425A0A0B4J230
ENSG00000130770ENST00000497986Q9UII2

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376891582024The pro-oncogenic protein IF(1) does not contribute to the Warburg effect and is not regulated by PKA in cancer cells.5
378042442024Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study.0
382804282024The inhibitor protein IF(1) from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex.2
376891582024The pro-oncogenic protein IF(1) does not contribute to the Warburg effect and is not regulated by PKA in cancer cells.5
378042442024Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study.0
382804282024The inhibitor protein IF(1) from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex.2
374337842023IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.5
374337842023IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.5
364996302022ATPase Inhibitory Factor 1-A Novel Marker of Cellular Fitness and Exercise Capacity?1
364996302022ATPase Inhibitory Factor 1-A Novel Marker of Cellular Fitness and Exercise Capacity?1
330650992021Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.17
336752162021Circulating Inhibitory Factor 1 levels in adult patients with Prader-Willi syndrome.1
339226432021ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.9
339294902021The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.6
330650992021Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.17

Citation

Dessen P

ATP5IF1 (ATP synthase inhibitory factor subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57371/css/lib/gene-explorer/favicon/favicon-32x32.png