SORBS1 (sorbin and SH3 domain containing 1)

2018-07-01  

Identity

HGNC
SORBS1
LOCATION
10q24.1
LOCUSID
10580
ALIAS
CAP,FLAF2,R85FL,SH3D5,SH3P12,SORB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10580
MIM: 605264
HGNC: 14565
Ensembl: ENSG00000095637

Variants:

dbSNP: 10580
ClinVar: 10580
TCGA: ENSG00000095637
COSMIC: SORBS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095637ENST00000277982Q9BX66
ENSG00000095637ENST00000306402Q9BX66
ENSG00000095637ENST00000354106Q9BX66
ENSG00000095637ENST00000361941Q9BX66
ENSG00000095637ENST00000371227Q9BX66
ENSG00000095637ENST00000371228Q5T925
ENSG00000095637ENST00000371239Q9BX66
ENSG00000095637ENST00000371241Q9BX66
ENSG00000095637ENST00000371245Q9BX66
ENSG00000095637ENST00000371246Q9BX66
ENSG00000095637ENST00000371247Q9BX66
ENSG00000095637ENST00000371249Q9BX66
ENSG00000095637ENST00000486141S4R303
ENSG00000095637ENST00000492542S4R406
ENSG00000095637ENST00000607232Q9BX66
ENSG00000095637ENST00000634504A0A0U1RQI5
ENSG00000095637ENST00000647619A0A3B3IRR9
ENSG00000095637ENST00000649575A0A3B3IRW8
ENSG00000095637ENST00000649911A0A3B3IT56

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
Adherens junctionKEGGko04520
Insulin signaling pathwayKEGGko04910
PPAR signaling pathwayKEGGhsa03320
Adherens junctionKEGGhsa04520
Insulin signaling pathwayKEGGhsa04910
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382127232024Increased serum extrachromosomal circular DNA SORBS1(circle) level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus.3
389150532024circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA.0
382127232024Increased serum extrachromosomal circular DNA SORBS1(circle) level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus.3
389150532024circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA.0
368548742023Down-regulation and clinical significance of Sorbin and SH3 domain-containing protein 1 in bladder cancer tissues.2
371649192023MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1.1
368548742023Down-regulation and clinical significance of Sorbin and SH3 domain-containing protein 1 in bladder cancer tissues.2
371649192023MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1.1
351072062022A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population.4
351961852022MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway.1
351072062022A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population.4
351961852022MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway.1
344099132021Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.13
344099132021Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.13
323195942020SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines.15

Citation

Dessen P

SORBS1 (sorbin and SH3 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57478/deep-insight-explorer/teaching-explorer/haematological-explorer/