NLGN4Y (neuroligin 4 Y-linked)

2018-07-01  

Identity

HGNC
NLGN4Y
LOCATION
Yq11.221
LOCUSID
22829
ALIAS
HNL4Y
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22829
MIM: 400028
HGNC: 15529
Ensembl: ENSG00000165246

Variants:

dbSNP: 22829
ClinVar: 22829
TCGA: ENSG00000165246
COSMIC: NLGN4Y

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165246ENST00000339174Q8NFZ3
ENSG00000165246ENST00000339174A0A024R9E7
ENSG00000165246ENST00000355905Q8NFZ3
ENSG00000165246ENST00000355905A0A024R9E7
ENSG00000165246ENST00000382868A6NMU8
ENSG00000165246ENST00000382872Q8NFZ3
ENSG00000165246ENST00000413217H0Y7G6
ENSG00000165246ENST00000643089B4DHI3
ENSG00000165246ENST00000645399A0A2R8YDT7

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
322437812020A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.29
322437812020A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.29
292298422018Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y.28
292298422018Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y.28
276266932016Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression.6
276266932016Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression.6
255589532015Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features.32
255589532015Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features.32
196057772009Association of Y chromosome haplotypes with autism.13
196057772009Association of Y chromosome haplotypes with autism.13
196057772009Association of Y chromosome haplotypes with autism.13
196057772009Association of Y chromosome haplotypes with autism.13
186286832008Analysis of the neuroligin 4Y gene in patients with autism.34
186286832008Analysis of the neuroligin 4Y gene in patients with autism.34
160777342005Analysis of four neuroligin genes as candidates for autism.60

Citation

Dessen P

NLGN4Y (neuroligin 4 Y-linked)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57485/js/teaching-explorer/