EIF5 (eukaryotic translation initiation factor 5)

2018-07-01  

Identity

HGNC
EIF5
LOCATION
14q32.32
LOCUSID
1983
ALIAS
EIF-5,EIF-5A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1983
MIM: 601710
HGNC: 3299
Ensembl: ENSG00000100664

Variants:

dbSNP: 1983
ClinVar: 1983
TCGA: ENSG00000100664
COSMIC: EIF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100664ENST00000216554P55010
ENSG00000100664ENST00000216554A0A024R6Q1
ENSG00000100664ENST00000392715P55010
ENSG00000100664ENST00000392715A0A024R6Q1
ENSG00000100664ENST00000558265H0YN40
ENSG00000100664ENST00000558316H0YLZ1
ENSG00000100664ENST00000558506P55010
ENSG00000100664ENST00000558506A0A024R6Q1
ENSG00000100664ENST00000559130H0YK11
ENSG00000100664ENST00000559532H0YM54
ENSG00000100664ENST00000560338H0YMJ8
ENSG00000100664ENST00000560763H0YK29
ENSG00000100664ENST00000561325H0YM54

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6
279867512017A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer.13
283855322017Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.4
289817282017Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.37
279867512017A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer.13
283855322017Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.4
289817282017Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.37
267179812016Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis.21
273257402016Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.26
267179812016Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis.21
273257402016Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.26
232930292013Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.48
243199942013The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.25
232930292013Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.48

Citation

Dessen P

EIF5 (eukaryotic translation initiation factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57535