OGDH (oxoglutarate dehydrogenase)

2018-07-01  

Identity

HGNC
OGDH
LOCATION
7p13
LOCUSID
4967
ALIAS
AKGDH,E1k,KGD1,OGDC,OGDH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4967
MIM: 613022
HGNC: 8124
Ensembl: ENSG00000105953

Variants:

dbSNP: 4967
ClinVar: 4967
TCGA: ENSG00000105953
COSMIC: OGDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105953ENST00000222673Q02218
ENSG00000105953ENST00000419661C9J4G7
ENSG00000105953ENST00000439616E9PFG7
ENSG00000105953ENST00000443864Q02218
ENSG00000105953ENST00000443864A0A140VJQ5
ENSG00000105953ENST00000444676E9PCR7
ENSG00000105953ENST00000447398E9PDF2
ENSG00000105953ENST00000449767Q02218
ENSG00000105953ENST00000631326A0A0D9SFS3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Citrate cycle (TCA cycle)KEGGhsa00020
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
384835412024OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma.0
384835412024OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma.0
365201522023Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.6
365201522023Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.6
323832942021A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease.15
323832942021A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease.15
320248852020Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues.17
321602762020DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.16
320248852020Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues.17
321602762020DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.16
312471902019OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer.18
312471902019OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer.18
283963872017PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.24
283963872017PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.24
269369702016Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.11

Citation

Dessen P

OGDH (oxoglutarate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57555