DGAT1 (diacylglycerol O-acyltransferase 1)

2018-07-01  

Identity

HGNC
DGAT1
LOCATION
8q24.3
LOCUSID
8694
ALIAS
ARAT,ARGP1,DGAT,DIAR7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8694
MIM: 604900
HGNC: 2843
Ensembl: ENSG00000185000

Variants:

dbSNP: 8694
ClinVar: 8694
TCGA: ENSG00000185000
COSMIC: DGAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185000ENST00000332324A0A0A0MR74
ENSG00000185000ENST00000528718O75907

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Retinol metabolismKEGGko00830
Glycerolipid metabolismKEGGhsa00561
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodeling of DAG and TAGREACTOMER-HSA-1482883
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379739512024Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress.0
385001572024The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.2
379739512024Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress.0
385001572024The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.2
366035762023DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.5
375163082023Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.1
377794212023The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background.1
378201172023Lipid droplets in Zika neuroinfection: Potential targets for intervention?0
366035762023DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.5
375163082023Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.1
377794212023The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background.1
378201172023Lipid droplets in Zika neuroinfection: Potential targets for intervention?0
357640912022An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.10
357640912022An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.10
337503502021Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer.8

Citation

Dessen P

DGAT1 (diacylglycerol O-acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57559/haematological-explorer/favicon/case-report-explorer/