TIFA (TRAF interacting protein with forkhead associated domain)

2018-11-01  

Identity

HGNC
TIFA
LOCATION
4q25
LOCUSID
92610
ALIAS
T2BP,T6BP,TIFAA

Other Information

Locus ID:

NCBI: 92610
MIM: 609028
HGNC: 19075
Ensembl: ENSG00000145365

Variants:

dbSNP: 92610
ClinVar: 92610
TCGA: ENSG00000145365
COSMIC: TIFA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145365ENST00000361717Q96CG3
ENSG00000145365ENST00000500655Q96CG3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365862742023The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.3
365862742023The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.3
356352392022TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner.1
356352392022TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner.1
342389832021TIFA protein expression is associated with pulmonary arterial hypertension.1
343282452021TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways.15
342389832021TIFA protein expression is associated with pulmonary arterial hypertension.1
343282452021TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways.15
329109972020TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.11
330372032020The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.35
329109972020TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.11
330372032020The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.35
303787292019Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.8
311238892019Role of NOD1 and ALPK1/TIFA Signalling in Innate Immunity Against Helicobacter pylori Infection.12
303787292019Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.8

Citation

Dessen P

TIFA (TRAF interacting protein with forkhead associated domain)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57674