CPLX2 (complexin 2)

2018-11-01  

Identity

HGNC
CPLX2
LOCATION
5q35.2
LOCUSID
10814
ALIAS
921-L,CPX-2,CPX2,Hfb1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10814
MIM: 605033
HGNC: 2310
Ensembl: ENSG00000145920

Variants:

dbSNP: 10814
ClinVar: 10814
TCGA: ENSG00000145920
COSMIC: CPLX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145920ENST00000359546Q6PUV4
ENSG00000145920ENST00000393745Q6PUV4
ENSG00000145920ENST00000502265D6RBA5
ENSG00000145920ENST00000509837D6RGY3
ENSG00000145920ENST00000512824D6RI05
ENSG00000145920ENST00000514150D6R960
ENSG00000145920ENST00000515025D6RDN3
ENSG00000145920ENST00000515094Q6PUV4

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384271332024CPLX2 is a novel tumor suppressor and improves the prognosis in glioma.0
384271332024CPLX2 is a novel tumor suppressor and improves the prognosis in glioma.0
361073872023CPLX2 Regulates Ferroptosis and Apoptosis Through NRF2 Pathway in Human Hepatocellular Carcinoma Cells.4
361073872023CPLX2 Regulates Ferroptosis and Apoptosis Through NRF2 Pathway in Human Hepatocellular Carcinoma Cells.4
278662312017Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.21
278662312017Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.21
252976952015Complexin2 modulates working memory-related neural activity in patients with schizophrenia.9
256923312015Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction.4
252976952015Complexin2 modulates working memory-related neural activity in patients with schizophrenia.9
256923312015Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction.4
255640262014Risk and protective effects of the complexin-2 gene and gene-environment interactions in schizophrenia.1
255640262014Risk and protective effects of the complexin-2 gene and gene-environment interactions in schizophrenia.1
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.7
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.17
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

CPLX2 (complexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57731/deep-insight-explorer/teaching-explorer/css/template-nav.css