AK6 (adenylate kinase 6)

2018-12-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
AD-004,CGI-137,CINAP,CIP,hCINAP

Other Information

Locus ID:

NCBI: 102157402
HGNC: 49151
Ensembl: ENSG00000085231

Variants:

dbSNP: 102157402
ClinVar: 102157402
TCGA: ENSG00000085231
COSMIC: AK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085231ENST00000380818Q9Y3D8
ENSG00000085231ENST00000380822Q9Y3D8
ENSG00000085231ENST00000502819A0A087WY94
ENSG00000085231ENST00000512561D6RDH4
ENSG00000085231ENST00000618980A0A087WVD7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
328305182021hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells.7
337442302021Human adenylate kinase 6 regulates WNK1 (with no lysine kinase-1) phosphorylation states and affects ion homeostasis in NT2 cells.2
342450112021Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression.5
328305182021hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells.7
337442302021Human adenylate kinase 6 regulates WNK1 (with no lysine kinase-1) phosphorylation states and affects ion homeostasis in NT2 cells.2
342450112021Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression.5
314443542019hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.26
322515572019[Expressions of the adenylate kinase family in asthenospermia].0
314443542019hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.26
322515572019[Expressions of the adenylate kinase family in asthenospermia].0
285169142017Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.38
285169142017Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.38
160791312005Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.21
160791312005Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.21
152133962004Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004.3

Citation

Dessen P

AK6 (adenylate kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57767/gene-fusions-explorer/css/lib/cancer-prone-explorer/