SURF4 (surfeit 4)

2018-12-01  

Identity

HGNC
SURF4
LOCATION
9q34.2
LOCUSID
6836
ALIAS
ERV29
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6836
MIM: 185660
HGNC: 11476
Ensembl: ENSG00000148248

Variants:

dbSNP: 6836
ClinVar: 6836
TCGA: ENSG00000148248
COSMIC: SURF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148248ENST00000371989O15260
ENSG00000148248ENST00000371991Q5T8U5
ENSG00000148248ENST00000485435O15260
ENSG00000148248ENST00000545297O15260
ENSG00000148248ENST00000613129B7Z1G8
ENSG00000148248ENST00000618229B7Z1G8

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365745932023Surf4, cargo trafficking, lipid metabolism, and therapeutic implications.6
365745932023Surf4, cargo trafficking, lipid metabolism, and therapeutic implications.6
349191272022Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.10
350513562022SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.12
352713962022A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.13
359012142022Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.12
363708472022Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.4
364463862022High SURF4 expression is associated with poor prognosis of breast cancer.3
349191272022Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.10
350513562022SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport.12
352713962022A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog.13
359012142022Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.12
363708472022Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.4
364463862022High SURF4 expression is associated with poor prognosis of breast cancer.3
331865572021Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.41

Citation

Dessen P

SURF4 (surfeit 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57783/css/lib/dataTables.bootstrap.min.css