DAOA (D-amino acid oxidase activator)

2019-04-01  

Identity

HGNC
DAOA
LOCATION
13q33.2
LOCUSID
267012
ALIAS
LG72,SG72

Other Information

Locus ID:

NCBI: 267012
MIM: 607408
HGNC: 21191
Ensembl: ENSG00000182346

Variants:

dbSNP: 267012
ClinVar: 267012
TCGA: ENSG00000182346
COSMIC: DAOA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182346ENST00000329625P59103
ENSG00000182346ENST00000375936P59103
ENSG00000182346ENST00000471432M0R2W9
ENSG00000182346ENST00000473269P59103
ENSG00000182346ENST00000473269A0A024RDZ4
ENSG00000182346ENST00000488534Q8IWM3
ENSG00000182346ENST00000489237M0R2M6
ENSG00000182346ENST00000559369P59103
ENSG00000182346ENST00000595812A2T115
ENSG00000182346ENST00000600388P59103
ENSG00000182346ENST00000601240M0R0L0
ENSG00000182346ENST00000618629P59103

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD19482054
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD19482054

References

Pubmed IDYearTitleCitations
327483162021Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.3
346815792021d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.6
327483162021Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.3
346815792021d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.6
315200712019pLG72 levels increase in early phase of Alzheimer's disease but decrease in late phase.9
315200712019pLG72 levels increase in early phase of Alzheimer's disease but decrease in late phase.9
291009742018The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population.5
300372902018pLG72 induces superoxide radicals via interaction and aggregation with SOD1.2
291009742018The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population.5
300372902018pLG72 induces superoxide radicals via interaction and aggregation with SOD1.2
274124972017Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker.9
278153202017Structure models of G72, the product of a susceptibility gene to schizophrenia.3
281663632017Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.7
282852462017The DAOA gene is associated with schizophrenia in the Taiwanese population.2
274124972017Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker.9

Citation

Dessen P

DAOA (D-amino acid oxidase activator)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57835