TNNI1 (troponin I1, slow skeletal type)

2019-04-01  

Identity

HGNC
TNNI1
LOCATION
1q32.1
LOCUSID
7135
ALIAS
SSTNI,TNN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7135
MIM: 191042
HGNC: 11945
Ensembl: ENSG00000159173

Variants:

dbSNP: 7135
ClinVar: 7135
TCGA: ENSG00000159173
COSMIC: TNNI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159173ENST00000336092P19237
ENSG00000159173ENST00000361379P19237
ENSG00000159173ENST00000367312P19237
ENSG00000159173ENST00000555340G3V489
ENSG00000159173ENST00000555948G3V3L5
ENSG00000159173ENST00000556362G3V4F8
ENSG00000159173ENST00000622580A0A087WT47

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Striated Muscle ContractionREACTOMER-HSA-390522

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385690172024Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.0
385690172024Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.0
331584992021Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.7
336837122021Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy.9
331584992021Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.7
336837122021Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy.9
325395412020Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19.43
325395412020Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19.43
304538902018Troponin I at admission in the intensive care unit predicts the need of dialysis in septic patients.0
304538902018Troponin I at admission in the intensive care unit predicts the need of dialysis in septic patients.0
285851212017Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population.6
287182452017Left Ventricular Systolic Dysfunction Predicted By Early Troponin I Release After Anthracycline Based Chemotherapy In Breast Cancer Patients.6
285851212017Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population.6
287182452017Left Ventricular Systolic Dysfunction Predicted By Early Troponin I Release After Anthracycline Based Chemotherapy In Breast Cancer Patients.6
269726312016Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study.28

Citation

Dessen P

TNNI1 (troponin I1, slow skeletal type)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57856/tnni1-(troponin-i1-slow-skeletal-type)