SMG7 (SMG7 nonsense mediated mRNA decay factor)

2019-04-01  

Identity

HGNC
SMG7
LOCATION
1q25.3
LOCUSID
9887
ALIAS
C1orf16,EST1C,SGA56M
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9887
MIM: 610964
HGNC: 16792
Ensembl: ENSG00000116698

Variants:

dbSNP: 9887
ClinVar: 9887
TCGA: ENSG00000116698
COSMIC: SMG7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116698ENST00000347615Q92540
ENSG00000116698ENST00000367537E9PD50
ENSG00000116698ENST00000419169B1ALB4
ENSG00000116698ENST00000440812E9PEK3
ENSG00000116698ENST00000444547E9PBK2
ENSG00000116698ENST00000502375D6R9J3
ENSG00000116698ENST00000507469Q92540
ENSG00000116698ENST00000507691D6RAD0
ENSG00000116698ENST00000508461Q92540
ENSG00000116698ENST00000515829Q92540
ENSG00000116698ENST00000638826E9PBK2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355117392022SNPs at SMG7 Associated with Time from Biochemical Recurrence to Prostate Cancer Death.1
355117392022SNPs at SMG7 Associated with Time from Biochemical Recurrence to Prostate Cancer Death.1
338209152021Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.1
341727242021SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.33
338209152021Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.1
341727242021SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.33
326025812020Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1.7
326025812020Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1.7
315115402019Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1.5
315115402019Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1.5
277718862017Frameshift Mutations of SMG7 Essential for Nonsense-Mediated mRNA Decay in Gastric and Colorectal Cancers.2
278644722017Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.104
284616252017Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.20
277718862017Frameshift Mutations of SMG7 Essential for Nonsense-Mediated mRNA Decay in Gastric and Colorectal Cancers.2
278644722017Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.104

Citation

Dessen P

SMG7 (SMG7 nonsense mediated mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57857