CYRIB (CYFIP related Rac1 interactor B)

2019-04-01  

Identity

HGNC
CYRIB
LOCATION
8q24.21
LOCUSID
51571
ALIAS
BM-009,CYRI,CYRI-B,FAM49B,L1

Other Information

Locus ID:

NCBI: 51571
MIM: 617978
HGNC: 25216
Ensembl: ENSG00000153310

Variants:

dbSNP: 51571
ClinVar: 51571
TCGA: ENSG00000153310
COSMIC: CYRIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153310ENST00000401979Q9NUQ9
ENSG00000153310ENST00000401979A0A024R9G4
ENSG00000153310ENST00000517654Q9NUQ9
ENSG00000153310ENST00000517654A0A024R9G4
ENSG00000153310ENST00000517672E5RK61
ENSG00000153310ENST00000518167E5RFS4
ENSG00000153310ENST00000518283E5RIR8
ENSG00000153310ENST00000519020E5RHU5
ENSG00000153310ENST00000519070E5RH75
ENSG00000153310ENST00000519110Q9NUQ9
ENSG00000153310ENST00000519110A0A024R9G4
ENSG00000153310ENST00000519142E5RI16
ENSG00000153310ENST00000519540Q9NUQ9
ENSG00000153310ENST00000519540A0A024R9G4
ENSG00000153310ENST00000519824Q9NUQ9
ENSG00000153310ENST00000519824A0A024R9G4
ENSG00000153310ENST00000520204E5RJL8
ENSG00000153310ENST00000520254E5RGI7
ENSG00000153310ENST00000522250Q9NUQ9
ENSG00000153310ENST00000522361E5RK81
ENSG00000153310ENST00000522746Q9NUQ9
ENSG00000153310ENST00000522746A0A024R9G4
ENSG00000153310ENST00000522941Q9NUQ9
ENSG00000153310ENST00000523509Q9NUQ9
ENSG00000153310ENST00000523509A0A024R9G4
ENSG00000153310ENST00000523993E5RJE1
ENSG00000153310ENST00000615041A0A087X178
ENSG00000153310ENST00000639004A0A1W2PRQ0

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

References

Pubmed IDYearTitleCitations
375401882024LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.0
387128222024CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.1
375401882024LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.0
387128222024CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.1
372649482023A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis.0
372649482023A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis.0
364997552022GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis.3
364997552022GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis.3
332173302021Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.7
332173302021Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.7
320715452020TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.19
320715452020TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.19
312855852019CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.23
312855852019CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.23
290591642018FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.35

Citation

Dessen P

CYRIB (CYFIP related Rac1 interactor B)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57975/css/lib/js/favicon/apple-touch-icon.png