MARCHF5 (membrane associated ring-CH-type finger 5)

2019-08-01  

Identity

HGNC
MARCHF5
LOCATION
10q23.32
LOCUSID
54708
ALIAS
MARCH-V,MARCH5,MITOL,RNF153

Other Information

Locus ID:

NCBI: 54708
MIM: 610637
HGNC: 26025
Ensembl: ENSG00000198060

Variants:

dbSNP: 54708
ClinVar: 54708
TCGA: ENSG00000198060
COSMIC: MARCHF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198060ENST00000358935Q9NX47

References

Pubmed IDYearTitleCitations
382118322024MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer.0
382118322024MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer.0
373374002023A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.0
374951092023Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.1
379324472023PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.3
373374002023A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.0
374951092023Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.1
379324472023PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.3
347479802022Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.21
347479802022Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.21
336118302021MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway.5
336570942021MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.6
340487292021The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.12
336118302021MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway.5
336570942021MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.6

Citation

Dessen P

MARCHF5 (membrane associated ring-CH-type finger 5)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58113