ANAPC11 (anaphase promoting complex subunit 11)

2021-06-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
APC11,Apc11p,HSPC214

Other Information

Locus ID:

NCBI: 51529
MIM: 614534
HGNC: 14452
Ensembl: ENSG00000141552

Variants:

dbSNP: 51529
ClinVar: 51529
TCGA: ENSG00000141552
COSMIC: ANAPC11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141552ENST00000344877Q9NYG5
ENSG00000141552ENST00000357385Q9NYG5
ENSG00000141552ENST00000357385A0A024R8S1
ENSG00000141552ENST00000392376Q9NYG5
ENSG00000141552ENST00000571024Q9NYG5
ENSG00000141552ENST00000571570Q9NYG5
ENSG00000141552ENST00000571874Q9NYG5
ENSG00000141552ENST00000572639Q9NYG5
ENSG00000141552ENST00000572851Q9NYG5
ENSG00000141552ENST00000574924Q9NYG5
ENSG00000141552ENST00000575195Q9NYG5
ENSG00000141552ENST00000577425J3QL35
ENSG00000141552ENST00000577747Q9NYG5
ENSG00000141552ENST00000578544J3QL35
ENSG00000141552ENST00000578550Q9NYG5
ENSG00000141552ENST00000579133J3QL35
ENSG00000141552ENST00000579978Q9NYG5
ENSG00000141552ENST00000582222J3QL35
ENSG00000141552ENST00000583839Q9NYG5
ENSG00000141552ENST00000584197J3QS46
ENSG00000141552ENST00000584314J3QL35
ENSG00000141552ENST00000585259J3KSK3
ENSG00000141552ENST00000612413A0A087X1B5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375733562023The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.1
375733562023The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.1
297436332018Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.7
297436332018Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.7
230079762012Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.4
230079762012Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.4
198264162010The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.60
208266192010Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.10
198264162010The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.60
208266192010Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.10
152562232004The RING-H2-finger protein APC11 as a target of hydrogen peroxide.15
152562232004The RING-H2-finger protein APC11 as a target of hydrogen peroxide.15
117397842001APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.74
117397842001APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.74

Citation

Dessen P

ANAPC11 (anaphase promoting complex subunit 11)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58201/js/css/lib/gene-fusions-explorer/