ANAPC11 (anaphase promoting complex subunit 11)

2021-06-01 Affiliation

Identity

HGNC

ANAPC11

LOCATION

17q25.3

LOCUSID

51529

ALIAS

APC11,Apc11p,HSPC214

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51529
MIM: 614534
HGNC: 14452
Ensembl: ENSG00000141552

Variants:

dbSNP: 51529
ClinVar: 51529
TCGA: ENSG00000141552
COSMIC: ANAPC11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000141552	ENST00000344877	Q9NYG5
ENSG00000141552	ENST00000357385	Q9NYG5
ENSG00000141552	ENST00000357385	A0A024R8S1
ENSG00000141552	ENST00000392376	Q9NYG5
ENSG00000141552	ENST00000571024	Q9NYG5
ENSG00000141552	ENST00000571570	Q9NYG5
ENSG00000141552	ENST00000571874	Q9NYG5
ENSG00000141552	ENST00000572639	Q9NYG5
ENSG00000141552	ENST00000572851	Q9NYG5
ENSG00000141552	ENST00000574924	Q9NYG5
ENSG00000141552	ENST00000575195	Q9NYG5
ENSG00000141552	ENST00000577425	J3QL35
ENSG00000141552	ENST00000577747	Q9NYG5
ENSG00000141552	ENST00000578544	J3QL35
ENSG00000141552	ENST00000578550	Q9NYG5
ENSG00000141552	ENST00000579133	J3QL35
ENSG00000141552	ENST00000579978	Q9NYG5
ENSG00000141552	ENST00000582222	J3QL35
ENSG00000141552	ENST00000583839	Q9NYG5
ENSG00000141552	ENST00000584197	J3QS46
ENSG00000141552	ENST00000584314	J3QL35
ENSG00000141552	ENST00000585259	J3KSK3
ENSG00000141552	ENST00000612413	A0A087X1B5

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
Ubiquitin mediated proteolysis	KEGG	ko04120
Progesterone-mediated oocyte maturation	KEGG	ko04914
Cell cycle	KEGG	hsa04110
Ubiquitin mediated proteolysis	KEGG	hsa04120
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
APC/C complex	KEGG	hsa_M00389
APC/C complex	KEGG	M00389
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
Mitotic Spindle Checkpoint	REACTOME	R-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	REACTOME	R-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complex	REACTOME	R-HSA-141430
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
Phosphorylation of the APC/C	REACTOME	R-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	REACTOME	R-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACTOME	R-HSA-174184
APC-Cdc20 mediated degradation of Nek2A	REACTOME	R-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin B	REACTOME	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	REACTOME	R-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	REACTOME	R-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACTOME	R-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/C	REACTOME	R-HSA-174084
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37573356	2023	The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.	1
37573356	2023	The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.	1
29743633	2018	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.	7
29743633	2018	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.	7
23007976	2012	Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.	4
23007976	2012	Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.	4
19826416	2010	The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.	60
20826619	2010	Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.	10
19826416	2010	The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.	60
20826619	2010	Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.	10
15256223	2004	The RING-H2-finger protein APC11 as a target of hydrogen peroxide.	15
15256223	2004	The RING-H2-finger protein APC11 as a target of hydrogen peroxide.	15
11739784	2001	APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.	74
11739784	2001	APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.	74

Citation

Dessen P

ANAPC11 (anaphase promoting complex subunit 11)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58201/js/css/lib/gene-fusions-explorer/