TRIM7 (tripartite motif containing 7)

2021-06-01  

Identity

HGNC
TRIM7
LOCATION
5q35.3
LOCUSID
81786
ALIAS
GNIP,RNF90

Other Information

Locus ID:

NCBI: 81786
MIM: 609315
HGNC: 16278
Ensembl: ENSG00000146054

Variants:

dbSNP: 81786
ClinVar: 81786
TCGA: ENSG00000146054
COSMIC: TRIM7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146054ENST00000274773Q9C029
ENSG00000146054ENST00000334421Q9C029
ENSG00000146054ENST00000393315Q9C029
ENSG00000146054ENST00000393319Q9C029
ENSG00000146054ENST00000422067Q9C029

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385091472024The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.2
385091472024The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.2
370235042023TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.3
370235042023TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.3
349367172022TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma.5
359822262022A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.10
360424812022GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.1
360677042022TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.25
364029432022Study on the expression of TRIM7 in peripheral blood mononuclear cells of patients with sepsis and its early diagnostic value.1
349367172022TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma.5
359822262022A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.10
360424812022GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.1
360677042022TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.25
364029432022Study on the expression of TRIM7 in peripheral blood mononuclear cells of patients with sepsis and its early diagnostic value.1
339896362021Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1.1

Citation

Dessen P

TRIM7 (tripartite motif containing 7)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58263