DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1)

2021-06-01  

Identity

HGNC
LOCATION
3p22.3
LOCUSID
ALIAS
DLC-A,DNCLI1,LIC1

Other Information

Locus ID:

NCBI: 51143
MIM: 615890
HGNC: 18745
Ensembl: ENSG00000144635

Variants:

dbSNP: 51143
ClinVar: 51143
TCGA: ENSG00000144635
COSMIC: DYNC1LI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144635ENST00000273130Q9Y6G9
ENSG00000144635ENST00000413350C9JGM7
ENSG00000144635ENST00000424991C9JLW1
ENSG00000144635ENST00000432458E9PHI6

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
347093602021Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.5
347093602021Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.5
323196482020Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.7
325132962020Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.37
323196482020Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.7
325132962020Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.37
306572582019DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells.7
306572582019DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells.7
295151262018A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.53
295151262018A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity.53
274820522016Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.76
275109482016Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.10
274820522016Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.76
275109482016Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.10
254223742014Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.15

Citation

Dessen P

DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58296/favicon/deep-insight-explorer/tumors-explorer/