CPT1C (carnitine palmitoyltransferase 1C)

2021-06-01  

Identity

HGNC
CPT1C
LOCATION
19q13.33
LOCUSID
126129
ALIAS
CATL1,CPT1-B,CPT1P,CPTI-B,CPTIC,SPG73

Other Information

Locus ID:

NCBI: 126129
MIM: 608846
HGNC: 18540
Ensembl: ENSG00000169169

Variants:

dbSNP: 126129
ClinVar: 126129
TCGA: ENSG00000169169
COSMIC: CPT1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169169ENST00000323446Q8TCG5
ENSG00000169169ENST00000323446A0A024QZE3
ENSG00000169169ENST00000392518Q8TCG5
ENSG00000169169ENST00000392518A0A024QZE3
ENSG00000169169ENST00000405931Q8TCG5
ENSG00000169169ENST00000405931A0A024QZI3
ENSG00000169169ENST00000594038M0R0D3
ENSG00000169169ENST00000594587M0R115
ENSG00000169169ENST00000595031M0R2H6
ENSG00000169169ENST00000595568M0R399
ENSG00000169169ENST00000595969M0R2B9
ENSG00000169169ENST00000596922M0R0D3
ENSG00000169169ENST00000597099M0R1F9
ENSG00000169169ENST00000598259M0R0D3
ENSG00000169169ENST00000598293Q8TCG5
ENSG00000169169ENST00000598293A0A024QZE3
ENSG00000169169ENST00000598396M0QZ13
ENSG00000169169ENST00000602019M0R2V3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387833462024APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.0
387833462024APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.0
366744682023Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer.0
366938362023To be or not to be a fat burner, that is the question for cpt1c in cancer cells.6
371518732023Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence.1
366744682023Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer.0
366938362023To be or not to be a fat burner, that is the question for cpt1c in cancer cells.6
371518732023Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence.1
326329822021Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.8
326329822021Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.8
322897512020Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.7
326419872020A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis.27
322897512020Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.7
326419872020A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis.27
300706972019Effects of carnitine palmitoyltransferases on cancer cellular senescence.0

Citation

Dessen P

CPT1C (carnitine palmitoyltransferase 1C)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58360