GPT2 (glutamic--pyruvic transaminase 2)

2021-06-01  

Identity

HGNC
GPT2
LOCATION
16q11.2
LOCUSID
84706
ALIAS
ALT2,GPT

Other Information

Locus ID:

NCBI: 84706
MIM: 138210
HGNC: 18062
Ensembl: ENSG00000166123

Variants:

dbSNP: 84706
ClinVar: 84706
TCGA: ENSG00000166123
COSMIC: GPT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166123ENST00000340124Q8TD30
ENSG00000166123ENST00000340124A0A024R6R2
ENSG00000166123ENST00000440783Q8TD30
ENSG00000166123ENST00000562132H3BU54

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine biosynthesisKEGGhsa00220
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369235302023The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.2
372873972023Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.1
369235302023The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.2
372873972023Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.1
351964982022Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.5
359087442022Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus.2
365271132022SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.4
351964982022Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.5
359087442022Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus.2
365271132022SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.4
333682912021Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy.11
338124072021[The Influence of Glutamic Pyruvate Transaminase 2 to Biological Characteristics of Acute Myeloid Leukemia Cell HL-60].0
333682912021Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy.11
338124072021[The Influence of Glutamic Pyruvate Transaminase 2 to Biological Characteristics of Acute Myeloid Leukemia Cell HL-60].0
319786132020A novel missense variant in GPT2 causes non-syndromic autosomal recessive intellectual disability in a consanguineous Iranian family.2

Citation

Dessen P

GPT2 (glutamic--pyruvic transaminase 2)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58388