Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10039
MIM: 607726
HGNC: 273
Ensembl: ENSG00000041880
Variants:
dbSNP: 10039
ClinVar: 10039
TCGA: ENSG00000041880
COSMIC: PARP3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Base excision repair | KEGG | ko03410 |
| Apoptosis | KEGG | ko04210 |
| Base excision repair | KEGG | hsa03410 |
| Apoptosis | KEGG | hsa04210 |
| BER complex | KEGG | hsa_M00296 |
| BER complex | KEGG | M00296 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32785980 | 2021 | Progress and outlook in studying the substrate specificities of PARPs and related enzymes. | 33 |
| 34066057 | 2021 | PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling. | 27 |
| 32785980 | 2021 | Progress and outlook in studying the substrate specificities of PARPs and related enzymes. | 33 |
| 34066057 | 2021 | PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling. | 27 |
| 29361132 | 2018 | Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. | 66 |
| 29520010 | 2018 | Dna is a New Target of Parp3. | 37 |
| 29676938 | 2018 | The Development of a Biotinylated NAD(+)-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay. | 3 |
| 30039287 | 2018 | PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines. | 16 |
| 29361132 | 2018 | Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. | 66 |
| 29520010 | 2018 | Dna is a New Target of Parp3. | 37 |
| 29676938 | 2018 | The Development of a Biotinylated NAD(+)-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay. | 3 |
| 30039287 | 2018 | PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines. | 16 |
| 29054115 | 2017 | Reversible mono-ADP-ribosylation of DNA breaks. | 94 |
| 29054115 | 2017 | Reversible mono-ADP-ribosylation of DNA breaks. | 94 |
| 27530147 | 2016 | PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). | 47 |
Citation
Dessen P
PARP3 (poly(ADP-ribose) polymerase family member 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/588/parp3
