GRK2 (G protein-coupled receptor kinase 2)

2003-11-01  

Identity

HGNC
GRK2
LOCATION
11q13.2
LOCUSID
156
ALIAS
ADRBK1,BARK1,BETA-ARK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 156
MIM: 109635
HGNC: 289
Ensembl: ENSG00000173020

Variants:

dbSNP: 156
ClinVar: 156
TCGA: ENSG00000173020
COSMIC: GRK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173020ENST00000308595P25098
ENSG00000173020ENST00000308595A0A0S2Z392
ENSG00000173020ENST00000526285E9PRV7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Olfactory transductionKEGGko04740
Hedgehog signaling pathwayKEGGhsa04340
Olfactory transductionKEGGhsa04740
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30616MAPK1GenePathwayassociated
PA320SLC12A1GenePathwayassociated23788015
PA39ADRB2GenePathwayassociated
PA62ATP1A1GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
382427022024GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.0
384462732024Exploring the potential biological function of GRK2 in colorectal cancer.0
382427022024GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.0
384462732024Exploring the potential biological function of GRK2 in colorectal cancer.0
366220652023Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.2
368019962023CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.2
378922342023G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.0
366220652023Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.2
368019962023CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.2
378922342023G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.0
353418062022GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.1
358787062022GRK2 in cardiovascular disease and its potential as a therapeutic target.3
360636012022The tyrosine phosphorylation of GRK2 is responsible for activated D(2)R-mediated insulin resistance.0
364615902022Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation.2
353418062022GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.1

Citation

Dessen P

GRK2 (G protein-coupled receptor kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/590/favicon/case-report-explorer/js/js/_common.js