AGR2 (anterior gradient 2, protein disulphide isomerase family member)

2003-02-01  

Identity

HGNC
AGR2
LOCATION
7p21.1
LOCUSID
10551
ALIAS
AG-2,AG2,GOB-4,HAG-2,HEL-S-116,HPC8,PDIA17,XAG-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10551
MIM: 606358
HGNC: 328
Ensembl: ENSG00000106541

Variants:

dbSNP: 10551
ClinVar: 10551
TCGA: ENSG00000106541
COSMIC: AGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106541ENST00000401412B5MC07
ENSG00000106541ENST00000412973C9J3E2
ENSG00000106541ENST00000419304O95994
ENSG00000106541ENST00000419304Q4JM46
ENSG00000106541ENST00000450569H7C3Z9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382887492024Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study.0
382887492024Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study.0
363296202023ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.4
366221902023AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment.0
371756012023Potential Role of AGR2 for Mammalian Skin Wound Healing.1
372847432023Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer.4
363296202023ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.4
366221902023AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment.0
371756012023Potential Role of AGR2 for Mammalian Skin Wound Healing.1
372847432023Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer.4
346566892022(125)I seeds inhibit proliferation and promote apoptosis in cholangiocarcinoma cells by regulating the AGR2-mediated p38 MAPK pathway.12
349130742022Anterior gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy‑induced senescence escape.6
349293762022Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells.9
349528322022A disorder clinically resembling cystic fibrosis caused by biallelic variants in the AGR2 gene.3
358579282022Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.5

Citation

Dessen P

AGR2 (anterior gradient 2, protein disulphide isomerase family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/595/js/lib/css/lib/gene-explorer/