AADAT (aminoadipate aminotransferase)

2014-11-01  

Identity

HGNC
AADAT
LOCATION
4q33
LOCUSID
51166
ALIAS
KAT2,KATII,KYAT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51166
MIM: 611754
HGNC: 17929
Ensembl: ENSG00000109576

Variants:

dbSNP: 51166
ClinVar: 51166
TCGA: ENSG00000109576
COSMIC: AADAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109576ENST00000337664Q8N5Z0
ENSG00000109576ENST00000337664Q4W5N8
ENSG00000109576ENST00000353187Q8N5Z0
ENSG00000109576ENST00000353187Q4W5N8
ENSG00000109576ENST00000502392D6RC56
ENSG00000109576ENST00000507375D6RFY7
ENSG00000109576ENST00000509167Q8N5Z0
ENSG00000109576ENST00000510340D6REB9
ENSG00000109576ENST00000515480Q8N5Z0
ENSG00000109576ENST00000515480Q4W5N8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine biosynthesisKEGGko00300
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Lysine biosynthesisKEGGhsa00300
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337672422021Expression analysis of selected genes involved in tryptophan metabolic pathways in Egyptian children with Autism Spectrum Disorder and learning disabilities.8
337672422021Expression analysis of selected genes involved in tryptophan metabolic pathways in Egyptian children with Autism Spectrum Disorder and learning disabilities.8
327686172020N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.17
327686172020N-Acetylcysteine Inhibits Kynurenine Aminotransferase II.17
297779392018Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development.9
303670592018Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.111
297779392018Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development.9
303670592018Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.111
287064362017The presence of kynurenine aminotransferases in the human cornea: Evidence from bioinformatics analysis of gene expression and immunohistochemical staining.5
287064362017The presence of kynurenine aminotransferases in the human cornea: Evidence from bioinformatics analysis of gene expression and immunohistochemical staining.5
267737452016Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.5
267737452016Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.5
241402522013Exercise affects symptom severity but not biological measures in depression and somatization - results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA.15
241402522013Exercise affects symptom severity but not biological measures in depression and somatization - results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA.15
214737612011Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.11

Citation

Dessen P

AADAT (aminoadipate aminotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60013