AARS1 (alanyl-tRNA synthetase 1)

2014-11-01  

Identity

HGNC
AARS1
LOCATION
16q22.1
LOCUSID
16
ALIAS
AARS,CMT2N,DEE29,EIEE29
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 16
MIM: 601065
HGNC: 20
Ensembl: ENSG00000090861

Variants:

dbSNP: 16
ClinVar: 16
TCGA: ENSG00000090861
COSMIC: AARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090861ENST00000261772P49588
ENSG00000090861ENST00000565361H3BPK7

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716

References

Pubmed IDYearTitleCitations
385124512024The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.0
386532382024Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.2
385124512024The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.0
386532382024Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.2
370100952023A humanized yeast model reveals dominant-negative properties of neuropathy-associated alanyl-tRNA synthetase mutations.1
370100952023A humanized yeast model reveals dominant-negative properties of neuropathy-associated alanyl-tRNA synthetase mutations.1
359711192022Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation.1
359711192022Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation.1
337534802021CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.15
339090432021Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy.15
337534802021CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.15
339090432021Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy.15
323142722020Alanyl-tRNA synthetase 1 (AARS1) gene mutation in a family with intermediate Charcot-Marie-Tooth neuropathy.12
323142722020Alanyl-tRNA synthetase 1 (AARS1) gene mutation in a family with intermediate Charcot-Marie-Tooth neuropathy.12
309521592019The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase.20

Citation

Dessen P

AARS1 (alanyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60019/favicon/meetings/meetings/